Organic Chemistry
We are interested on the preparation of new heterocyclic compounds containing indole, benzofuran, quinoline and benzothiophene-2-carboxamide derivatives then investigate them as potential anticancer agents.
In addition, synthesis of new organic derivatives of barbituric and meldrum's acids; which may exhibit antibacterial and antifungal activities.
Characterization of the target products using spectroscopic techniques (NMR, IR), MS, elemental analysis and single crystal X-ray diffraction.
Pharmaceutical Instrumental Analysis
- Isolation, identification and synthesis of impurities/degradants in pharmaceutical raw materials and finished products.
- Semi-preparative HPLC and plate chromatography for isolation purpose.
- LC/MS and 2D-NMR techniques for characterization the target impurities.
- Development and validation of HPLC methods for analysis pharmaceutical active ingredients and their related impurities.