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Dietary polyacetylenes, falcarinol and falcarindiol, prevents the formation of neoplastic lesions in the colon of azoxymethaneinduced rats In Chemistry Department 22 Nov 2017

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The seminars committee at the Chemistry Department at the University of Jordan invites you for a lecture titled:
تتشرف لجنة الندوات في قسم الكيمياء/ الجامعة الأردنية بدعوتكم لحضور محاضرة علمية بعنوان:

 

 Dietary polyacetylenes, falcarinol and falcarindiol, prevents the formation of neoplastic lesions in the colon of azoxymethaneinduced rats

 
Dr. Rime B. El-Houri
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark
Odense - Denmark
د. ريم الحوري
استاذ مساعد /قسم الهندسة الكيميائية, التكنولوجيا الحيوية والتكنولوجيا البيئية
جامعة جنوب الدنمارك
اودنسا- الدنمارك
Place: Seminar Room, Department of Chemistry
المكان : قاعة النشاطات / قسم الكيمياء
 
Date & Time: Wednesday 22/11/2017 at 2:00 pm
الزمان: الاربعاءد 22/11/2017 في تمام الساعة 2:00 بعدالظهر
 
 
ABSTRACT
 The polyacetylenes falcarinol (FaOH) and falcarindiol (FaDOH) are found in many food plants of the Apiaceae family. Carrots are a major dietary source of these polyacetylenes. Feeding azoxymethane (AOM)-induced rats with carrots and purified FaOH have previously been shown to inhibit neoplastic transformations in the colon. FaOH and FaDOH have also shown to have a synergistic effect in vitro, resulting in a significant increased cytotoxic activity. Based on these findings the antineoplastic effect of FaOH and FaDOH purified from carrots (purity > 99%) was investigated in the AOM-induced rat model. Twenty rats received rat diet containing 7 μg FaOH per g feed and 7 μg FaDOH per g feed and 20 rats were controls receiving only rat diet. Then carcinogenesis was induced in all 40 rats with the carcinogen AOM. All animals received the designated diet for 2 weeks before AOM induction and continued on the designated diet throughout the experiment. Rats were euthanized 18 weeks after the first AOM injection and macroscopic polyp/cancers were measured, harvested and stained for histology. The number of small ACF clusters was reduced by 26.6% (P < 0.001), number of large ACF clusters reduced by 56.7% and (P = 0.027), and finally the number of tumors larger than 3 mm were reduced by 83.3% (P = 0.032) in treated rats compared to controls. In conclusion dietary supplements with FaOH and FaDOH reduced the number of neoplastic lesions as well as the growth rate of the polyps suggesting a preventive effect of FaOH and FaDOH on the development of colorectal cancer.
 

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